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Cox Inhibition May Fight Heart Attacks
Cherry Advantage 3
Courtesy of the Cherry Marketing Institute:
Research by scientists at the University of Pennsylvania School of Medicine has
demonstrated that aspirin, ibuprofen and other COX inhibitors may aid
substantially in preventing heart disease, slowing the build-up of plaque in
blood vessels by more than 50 percent.
"The cyclooxegenase enzyme known as COX-1 may play a role in the gradual
hardening of the arteries that precedes acute events like heart attack or
stroke," said Garret A. FitzGerald, MD, chairman of Penn's Department of
Pharmacology. Medicines that inhibit the COX enzyme, such as aspirin, do not
speed up the development of arteriosclerosis and can help protect against heart
attack and stroke.
Using mice that had been engineered to produce high levels of cholesterol, the
scientists analyzed the mice's aortas at the conclusion of the 16-week study.
The researchers found that lesions were reduced by 55 percent in mice exposed to
the COX inhibitor, compared to lesions in the untreated mice.
Although more data in needed in support of the extrapolation, it is entirely
logical that the same enzymes that make cherries effective in blocking the pain
messages carried by the COX enzyme would also make cherries effective in
protecting against heart attack and stroke.
David Ropa, a consultant with Thomas J. Payne Development, compiled the
information on the most recent research projects on cherries.
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